NEWS
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Our cover in Developmental Cell!
We made it! Our cover image was selected for the latest issue of Developmental Cell, have a peep here: https://www.cell.com/developmental-cell/issue?pii=S1534-5807(19)X0014-3#
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Our last publication in Developmental Cell
You may think the extracellular matrix is always long-lived. Check out our new paper http://zpr.io/HnJFF showing rapid turnover of ECM in embryos, a team effort combining modelling and experiment. Yutaka Matsubayashi, Besaiz Jose Sánchez-Sánchez et al. tell us about the rapid turnover of embryonic extracellular matrix during tissue morphogenesis. We imaged the de novo deposition of basement membrane in Drosophila embryos from initiation to homeostasis and mathematically modelled protein dynamics to quantify synthesis and degradation rates. The model predicted a rapid turnover of basement membrane proteins with half-lives of ~7-10 h. This finding was confirmed by in vivo pulse-chase and photoconversion experiments, thanks to a novel Collagen-Scarlet probe and a photoswitchable Collagen-EOS. Inhibiting proteolysis or ECM interactions alters the basal turnover rate, which in turn affects the normal embryonic development of the central nervous system. This rapid ECM turnover contrasts with studies in adult animals suggesting half-lives on the order of months to years. We hypothesise that a liable ECM network is likely necessary to maintain plasticity for growth and morphogenesis.
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Developmental Dance
What if we told you that Drosophila macrophages had a sense of rhythm? And that they like some Latin groove?
If you don't believe us, look at how this amazing model for studying cell migration perform on the (embryonic) dance floor! |
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Socialising (before the distancing)Here is a picture of our cheerful faces just before one of our seasonal lab socials! It was December 2019 and little did we know that socialising (without distancing) would be put on hold for a while. We went out for Spanish food in Farringdon for Christmas (and newly published paper!) celebrations. Now we are all scattered around London working from home and we look forward to when another dinner together will be allowed. Rumour has it it’s going to be Mexican food next time…
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Persistent and polarized global actin flow is essential for directionality during cell migration
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Our last publication in Nature of Cell Biology
In our last paper, "Persistent and polarized global actin flow is essential for directionality during cell migration", we study the cues that determine the direction of cell migrating cells. We exploit the embryonic migration of Drosophila macrophages to bridge the different temporal scales of the behaviours controlling motility. Our results show that cell migration directionality does not correlate with the dynamics of the leading edge but with the flow of the actin network behind the leading edge. Quantification of actin flow structure during migration reveals a stable organisation and asymmetry in the cell-wide flow field that strongly correlates with cell directionality. This organisation is regulated by a gradient of actin network compression and destruction, which is controlled by myosin contraction and cofilin-mediated disassembly. It is this stable actin-flow polarity, which integrates rapid fluctuations of the leading edge, that controls inherent cellular persistence.
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The Randall Centre for Cell & Molecular BiophysicsThe Randall Centre for Cell & Molecular Biophysics is a vibrant research environment, hosting labs working in burgeoning fields in biomedicine. Research in our Centre addresses fundamental biological questions at the interface between the physical and biomedical sciences. We develop and apply state-of-the-art biophysical techniques and address molecular and cellular processes in biology and medicine. We study these biological processes at the molecular, cellular and tissue scales.
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